Dr. Alberto Davalli
Diabetologo ed endocrinologo
Diabetologia, Endocrinologia, Medicina interna
Curriculum
Il dottor Alberto Davalli è dirigente medico senior presso l’Unità Operativa di Medicina Generale a indirizzo endocrino-diabetologico dell’IRCCS Ospedale San Raffaele diretta dal professor Emanuele Bosi.
Dopo la laurea in Medicina e chirurgia presso l’Università degli Studi di Milano nel 1985, si specializza in Diabetologia e Malattie del Ricambio nel 1989 e in Endocrinologia e Malattie Metaboliche nel 2004 presso la medesima università.
Il dottor Davalli svolge la propria attività clinica in reparto e in sede ambulatoriale come internista, diabetologo ed endocrinologo.
Dal punto di vista dell’attività di ricerca, il dottor Davalli ha ricoperto diversi ruoli di rilievo, a livello nazionale e internazionale, in merito alla ricerca diabetologica e endocrinologica. E’ autore e coautore di 90 pubblicazioni su riviste scientifiche di settore e capitoli di libri. Il suo H index è di 34. Partecipa costantemente a congressi nazionali ed internazionali del settore.
Pubblicazioni
Abnormal sensitivity to glucose of human islets cultured in a high glucose medium: partial reversebility after an additional culture in a normal glucose medium.
Davalli AM, Ricordi C, Socci C, Braghi S, Bertuzzi F, Fattor B, Di Carlo V, Pontiroli AE, Pozza G.
J Clin Endocrinol Metab 72 (1): 202-208, 1991
Human islets chronically exposed in-vitro to different stimuli become unresponsive to the same stimuli given acutely: evidence supporting specific desensitization rather than b-cell exhaustion.
Davalli AM, Pontiroli AE, Socci C, Bertuzzi F, Fattor B, Braghi S, Di Carlo V, Pozza G.
J Clin Endocrinol Metab, 74:790-794, 1992
Paradoxical release of insulin by adult pig islet in-vitro: recovery after culture in a defined tissue culture medium.
Davalli AM, Bertuzzi F, Socci C, Scaglia L, Gavazzi F, M. Freschi, Di Carlo V, Pontiroli AE, Pozza G.
Transplantation, 56: 148-154, 1993
Loss of glucose-induced insulin secretion and Glut 2 expression in transplanted beta cells.
Ogawa Y, Noma Y, Davalli AM, WU Y-J, Thorens B, Bonner-Weir S, Weir GC.
Diabetes, 44:75-79, 1995
Function, mass, and replication of porcine and rat islets transplanted into diabetic nude mice.
Davalli AM, Ogawa Y, Scaglia L, Wu Y-J, Hollister Jennifer, Bonner-Weir S, Weir GC.
Diabetes, 44:104-111, 1995
Selective decrease in the beta cell mass of human islets transplanted into diabetic nude mice.
Davalli AM, Ogawa Y, Ricordi C, Scharp DW, Bonner-Weir S, Weir GC.
Transplantation, 59:817-820, 1995
Long-term normalization of GLUT-4 protein content in skeletal muscle of diabetic rats following islet transplantation.
Davalli AM, Napoli R, Weitgasser R, Hirshman MF, Capotorto JV, Finegood DT, Bonner-Weir S, Horton ES, Weir GC.
Journal of Endocrinology, 150:255-263, 1996
Islet transplantation under the kidney capsule fully corrects the impaired skeletal muscle glucose transport system of streptozotocin diabetic rats.
Napoli R, Davalli AM, Hirshman MF, Weitgasser R, Weir GC, Horton ES.
J Clin Invest, 97: 1389-1397, 1996
Vulnerability of islets in the immediate post-transplantation period: dynamic changes in structure and function
Davalli AM, Scaglia L, Zangen DH, Hollister J, Bonner-Weir S, Weir GC.
Diabetes, 45:1161 - 1167, 1996
Insulin-secreting nonislet cells are resistant to autoimmune destruction
Lipes MA, Cooper E, Skelly R, Rhodes CJ, Boschetti EV, Weir GC, Davalli AM.
Proc. Natl. Acad. Sci. (USA), 93:8595-8600, 1996
Pituitary cotransplantation significantly improves the performance, insulin content, and vascularization of renal subcapsular islet grafts
Davalli AM, Scaglia L, Brevi M, Sanvito F, Freschi M, Cavallaro U, Parlow A, Pontiroli AE.
Diabetes, 48:59-65,1999
Insights from a successful case of intrahepatic islet transplantation into a type 1 diabetic patient
Davalli AM, Maffi P, Socci C, Sanvito F, Freschi M, Bertuzzi F, Falqui L, Di Carlo V, Pozza G, Secchi A.
J Clin Endocrinol Metab, 85:3847-3852, 2000
The GLP-1 receptor agonists exenatide and liraglutide activate Glucose transport by an AMPKdependent mechanism
Andreozzi F, Raciti GA, Nigro C, Mannino GC, Procopio T, Davalli AM, Beguinot F, Sesti G, Miele C, Folli F.
J Transl Med. 2016 Jul 30;14(1):229
The glial glutamate transporter 1 (GLT1) is expressed by pancreatic beta-cells and prevents glutamate-induced beta-cell death
Di Cairano ES, Davalli AM, Perego L, Sala S, Sacchi VF, La Rosa S, Finzi G, Placidi C, Capella C, Conti P, Centonze VE, Casiraghi F, Bertuzzi F, Folli F, Perego C.
J Biol Chem. 2011 Apr 22;286(16):14007-18
Halff GA, DeFronzo RA, Folli F.Exenatide regulates pancreatic islet integrity and insulin sensitivity in the nonhuman primate baboon Papio hamadryas.
Fiorentino TV, Casiraghi F, Davalli AM, Finzi G, La Rosa S, Higgins PB, Abrahamian GA, Marando A, Sessa F, Perego C, Guardado-Mendoza R, Kamath S, Ricotti A, Fiorina P, Daniele G, Paez AM, Andreozzi F, Bastarrachea RA, Comuzzie AG, Gastaldelli A, Chavez AO, Di Cairano ES, Frost P, Luzi L, Dick EJ,
JCI Insight. 2019 Oct 17;4(20).