Senescence in stem cell aging, differentiation and cancer

SR-Tiget Unit
Raffaella Di Micco, SR-Tiget Group Leader


Our research team is interested in dissecting the transcriptional and epigenetic mechanisms that regulate cellular senescence during aging, differentiation and cancer. Gene transcription and chromatin conformation orchestrate the tightly controlled transcriptional program of cellular senescence. However, very little is known on how the identity of senescence cells is established and how it contributes to fundamental biological processes such as cancer, organismal aging and cellular differentiation. In the hematopoietic stem cell compartment (HSPCs) aging results from the inability of HSPC to replenish short-lived cells and guarantee tissue homeostasis. The functional deterioration of the hematopoietic axis associates with a progressive reduction in immune response and an increased incidence of anemia and myelodisplastic disorders in the elderly. To date, the functional role of senescence-associated pathways and regulators in human HSPC aging, in stressed hematopoiesis and during cancer development remains largely unexplored. If you are interested in working with us, please contact dimicco.raffaella@hsr.it. We are always looking for smart, highly motivated and enthusiastic people to join our team. Computational biologists are also encouraged to apply.

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