The Movement Disorders Unit is focused on understanding the physiopathological mechanisms responsible for different movement disorders, arising from both central and peripheral nervous system dysfunctions. We are involved in the clinical and neurophysiological validation studies on safety and efficacy of innovative therapeutic strategies, both in clinical practice and in experimental settings. In particular we are studying several animal models of human acquired and inherited diseases in order to characterize underlying physiopathological mechanism and to provide a sensitive model to verify the response to experimental therapies. Further, we are committed in the translation process of these new therapeutic approach in human pathology, like the deep brain stimulation in several basal ganglia disorders or lentiviral hematopoietic stem cell gene therapy in metachromatic leukodystrophy. Notably we are studying the functional recovery after botulinum toxin type A (BT-A) therapy in patients with focal spasticity in multiple sclerosis (MS), the tuning of the treatment of neurogenic bladder by BT-A injection into the detrusor muscle, as well as the cortical excitability modifications in dystonic diseases.