martino_personalecopia

Neuroimmunology

INSPE UNIT
Gianvito Martino, Head of Unit

martino.gianvito@hsr.it

Physiological (spontaneous) and reactive (reparative) regenerative processes are fundamental part of life and greatly differ among the different animals and tissues. While spontaneous regeneration naturally occurs upon cell attrition, reparative regeneration occurs as a consequence of tissue damage. Both spontaneous and reparative regeneration play an important role in maintaining the normal equilibrium of the central nervous system (CNS) as well as in promoting its repair upon injury. The Unit’s research activity is mainly focused on the study of the molecular and cellular pathways sustaining both spontaneous and reparative CNS regenerative processes in both the healthy and pathological conditions such as inflammation and neurodegeneration. The ultimate main goal of the unit is to develop more efficacious therapeutic strategies to combat still incurable CNS pathological conditions.

Selected publications

Onorati M*, Castiglioni V*, Biasci D**, Cesana E**, Menon R**, Vuono R, Talpo F, Goya RL, Lyons P, Bulfamante GP, Muzio L, Martino G, Toselli M, Farina C, Barker RA, Biella G, Cattaneo E. Molecular and functional definition of the developing human striatum. Nat. Neurosci. 2014. 17:1804-1815 [Epub ahead of print on November 10, 2014] (*equally contributed; **equally contributed)

Arnò B, Grassivaro F, Rossi C, Bergamaschi A, Greter M, Favaro R, Comi G, Becher B, Martino G*, Muzio L*. Neural progenitors cells orchestrate microglia migration and positioning into the developing cortex. Nat. Comm. 2014. 5:5611. (*equally contributed)

Laterza C, Merlini A, De Feo D, Ruffini F, Menon R, Onorati M, Fredrickx E, Muzio L, Lombardo A, Comi G, Quattrini A, Taveggia C., Farina C, Cattaneo E, Martino G. iPSC-derived neural precursors exert a neuroprotective role in immune-mediated demyelination via the secretion of leukemia inhibitory factor. Nat Commun. 2013. 4:2597.

Peruzzotti-JamettiL*, Cambiaghi M*, Bacigaluppi M, Gallizioli M, Gaude E, Cursi M, Mari S, Sandrone S, Teneud L, Comi G, Musco G, Martino G*, Leocani L*. Cathodal tDCS prevents neuronal damage in the very acute phase of ischemic stroke. Stroke. 2013. 44:3166-3174 [Epub ahead of print on August 27, 2013] (*equally contributed)

Nigro A, Menon R, Bergamaschi A, Clovis Y, Baldi A, De Pietri Tonelli D, Comi G, Farina C, Martino G*, Muzio L*. MiR-30 and miR-181d control radial glia cell proliferation via HtrA1 modulation. Cell Death Dis. 2012. 3:e360 [Epub ahead of print on August 2, 2012]. (*equally contributed)

Butti E*, Bacigaluppi M*, Rossi S, Cambiaghi M, Bari M, Cebrian Silla A, Brambilla E, MusellaA, De Ceglia R, Teneud L, De Chiara V, D’adamo P, Garcia-Verdugo JM, Comi G, Muzio L, Quattrini A, Leocani L, Maccarrone M, Centonze D, Martino G. Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitoxicity. Brain. 2012. 115:3320-3335 [Epub ahead of print on Sep. 24, 2012]. (IF ’12, 9.915) (*equally contributed)

Kokaia Z*, Martino G*, Schwartz M*, Lindvall O. Cross-talk between neural stem cells and immune cells: the key to better brain repair? Nat Neurosci. 2012. 15:1078-1087 (*equally contributed).

Martino G, Pluchino S, Bonfanti L, Schwartz M. Brain regeneration in physiology and pathology: the immune signature driving therapeutic plasticity of neural stem cells. Physiol Rev. 2011. 91:1281-1304.

Martino G, Franklin RJ, Van Evercooren AB, Kerr DA, The Stem Cells in Multiple Sclerosis (STEMS) consensus group. Stem cell transplantation in multiple sclerosis: current status and future prospects. Nat Rev Neurol. 2010. 6:247–255.

Pluchino S*, Gritti A*, Blazer E, Amadio S, Brambilla E, Borsellino G, Cossetti C, Del Carro U, Comi G, ‘T Hart B, Vescovi A, Martino G. Human neural stem cells ameliorate autoimmune encephalomyelitis in non human primates. Ann Neurol. 2009. 66:343-354 (*equally contributed)

Shechter R, London A, Varol C, Cusimano M, Raposo C, Rolls A, Pluchino S, Martino G, Jung S, Schwartz M. Infiltrating blood-borne monocytes display an anti-inflammatory role in supporting recovery from spinal cord injury. PLoS Med. 2009. 6:e1000113.

Bacigaluppi M*, Pluchino S*, Kilic E, Peruzzotti-Jametti L, Kilic U, Salani G, Brambilla E, Comi G, Martino G*, Hermann DM*. Delayed post-ischemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms. Brain. 2009.132:2239-51 (*equally contributed).

Centone D*, Muzio L*, Rossi S, Cavasinni F, De Chiara V, Bergami A, Musella A, D’Amelio M, Cavallucci V, Martorana A, Bergamaschi A, Concioni MT, Diamantini A, Butti E, Comi G, Bernardi G, Cecconi F, Battistini L, Furlan R, Martino G. Inflammation triggers synaptic alteration and degeneration in experimental autoimmune encephalomyelitis. J. Neurosci. 2009. 29:3442-3452 (*equally contributed).

Pluchino S, Muzio L, Imitola J, Deleidi M, Alfaro-Cervello C, Salani G, Porcheri C, Brambilla E, Bergamaschi A, Garcia-Verdugo JM, Comi G, Khoury SJ*, Martino G*. Chronic inflammation induces a non cell-autonomous dysfunction of the endogenous brain stem cell compartment. (*equally contributed) Brain. 2008. 131:2564-2578 [Epub ahead of print on Aug 30, 2008].

Furlan R, Bergami A, Brambilla E, Butti E, De Simoni MG, Campagnoli M, Marconi P, Comi G, Martino G. HSV-1-mediated IL-1 receptor antagonist gene therapy ameliorates MOG35-55 induced experimental autoimmune encephalomyelitis in C57BL/6 mice. Gene Ther. 2007. 14:93-98 (Epub ahead of print, August 24, 2006).

Ziv Y, Avidan H, Pluchino S, Martino G, Schwartz M. Synergy between immune cells and adutl stem/progenitor cells promote functional recovery from spinal cord injury. Proc. Natl. Acad. Sci. USA. 2006. 103:13174-13179.

Martino G, Pluchino S. The therapeutic potential of neural stem cells. Nat. Rev. Neurosci. 2006. 7:395-406.

Pluchino S, Zanotti L, Rossi B, Brambilla E, Ottoboni L, Salani G, Martinello M, Cattalini A, Bergami A, Furlan R, Comi G, Constantin G, Martino G. Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism. Nature. 2005. 436:266-271.

Martino G. How the brain repairs itself: perspectives for new therapeutic strategies for inflammatory and degenerative CNS disorders. Lancet Neurol. 2004. 3:372-378.

Pluchino S, Quattrini A, Brambilla E, Gritti A, Salani G, Dina G, Galli R, Bergami A, Furlan R, Del Carro U, Amadio S, Comi G, Vescovi AL, Martino G. Injection of adult neurospheres induce clinical recovery in a chronic model of multiple sclerosis. Nature. 2003. 422:688-694.

Furlan R, Brambilla E, Sanvito F, Roccatagliata L, OlivieriS, Bergami A, Pluchino S, Uccelli A, Comi G, Martino G. Vaccination with amyloid-beta peptide induces autoimmune encephalomyelitis. Brain. 2003. 126;285-291.

 

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