Institute of Experimental Neurology (INSPE)

Director: Giancarlo Comi

The Institute of Experimental Neurology (INSPE) constitutes one of the major European institutes primarily dedicated to translational research in the neuroscience field. The overall ambition is to conjugate high level of basic research with the specific competences in pre-clinical and clinical research. This is achievable considering that INSPE includes both research laboratories and the Neurological Department of the San Raffaele Scientific Institute. Inflammatory and neurodegenerative disorders of the central and peripheral nervous system, stroke, spinal cord nerve and traumatic injures represents the primary targets of the INSPE research.
The primary goal is to better understand the molecular mechanisms that sustain inflammatory and degenerative pathogenic mechanisms underlying neurological disorders so to identify therapeutic targets, validate in co-operation with pharma companies new treatments, develop new disease biomarkers for both clinical trials and patients monitoring. The neurological department is deeply involved in the definition of new treatment algorithms for stroke, inflammatory and neurodegenerative diseases. The molecular and functional bases for central and peripheral nervous system recovery processes and the potential to modulate them by cellular and gene therapy and by specific rehabilitation interventions are another area of interest of INSPE.
The INSPE laboratories spans on four different levels in DIBIT2 buildings.
One floor is dedicated to neuropathology, experimental neurophysiology, neurogenetics of monogenic and complex diseases. Another floor is dedicated to basic and clinical neuroimmunology, neurobiology, neural stem cell research and neuroembriology. The third floor is focused on neuroimaging of neuroinflammatory and neurodegenerative disorders. The fourth floor includes labs on experimental imaging and molecular biology. Other laboratories involved in behavioral research and in signals that regulate myelination and in clinical neurophysiology are also part of the Institute. Finally the MAGICS Center which studies effects on magnetic stimulation of the brain complete the research area.

 

Research units/clinic research groups