Simone Cenci

Age related diseases

Simone Cenci, Group Leader

cenci.simone@hsr.it



Our lab studies the biology of normal plasma cells (PC), terminally differentiated effectors of Ab responses, and their malignant degeneration, multiple myeloma (2% of all cancer deaths). We are interested in the role of autophagy in PC ontogenesis and myeloma, in search for new prognostic markers and molecular targets against PC malignancies. Synergic studies on the skeletal microenvironment and bone cells explore the vicious relationship of myeloma with the bone marrow.

Selected Publications

Cenci S. Autophagy, a new determinant of plasma cell differentiation and antibody responses. Mol Immunol. 2014. http://dx.doi.org/10.1016/j.molimm.2014.02.008 . Review.

Oliva L, Cenci S. Autophagy in Plasma Cell Pathophysiology. Front Immunol. 2014. 5:103. eCollection 2014. Review.

Benasciutti E, Mariani E, Oliva L, Scolari M, Perilli E, Barras E, Milan E, Orfanelli U, Fazzalari NL, Campana L, Capobianco A, Otten L, Particelli F, Acha-Orbea H, Baruffaldi F, Faccio R, Sitia R, Reith W and Cenci S. MHC Class II Transactivator is an in vivo regulator of osteoclast differentiation and bone homeostasis co-opted from adaptive immunity. J Bone Min Res. 2014. 29(2):290-303

Pengo N, Scolari M, Oliva L, Milan E, Mainoldi F, Raimondi A, Fagioli C, Merlini A, Mariani E, Pasqualetto E, Orfanelli U, Ponzoni M, Sitia R, Casola S and Cenci S. Plasma cells require autophagy for sustainable immunoglobulin production. Nat Immunol. 2013. 14(3):298-305.

Pengo N and Cenci S. The role of autophagy in plasma cell ontogenesis. Autophagy. 2013. 9(6):942-4.

Cenci S. The proteasome in terminal plasma cell differentiation. Semin Hematol. 2012. 49(39):215–222. Review

Cenci S, Oliva L, Cerruti F, Milan E, Bianchi G, Raule M, Mezghrani A, Pasqualetto E, Sitia R, Cascio P. Pivotal advance: Protein synthesis modulates responsiveness of differentiating and malignant plasma cells to proteasome inhibitors. J Leukoc Biol. 2012. 92(5):921-31.

Cenci S, van Anken E, Sitia R. Proteostenosis and plasma cell pathophysiology. Curr Opin Cell Biol. 2011. 23(2):216-22. Review

Bianchi G, Oliva L, Cascio P, Pengo N, Fontana F, Cerruti F, Orsi A, Pasqualetto E, Mezghrani A, Calbi V, Palladini G, Giuliani N, Anderson KC, Sitia R and Cenci S. The proteasome load vs. capacity balance determines apoptoptic sensitivity of multiple myeloma cells to proteasome inhibition. Blood. 2009. 113:3040-3049

Cenci S, Mezghrani A, Cascio P, Cerruti F, Mattioli L, Oliva L, Orsi A, Masciarelli S, Ruffato E, Pasqualetto E, Sitia R. Progressively impaired proteasomal capacity during terminal plasma cell differentiation. EMBO J. 2006. 25(5):1104-13

Cenci S, Toraldo G, Weitzmann MN, Roggia C, Gao Y, Qien WP, Sierra O, Pacifici R. Estrogen deficiency causes bone loss by upregulating T cell proliferation and lifespan through IFNγ induced class II transactivator. Proc Natl Acad Sci USA. 2003. 100(18): 10405-10

Cenci S, Weitzmann MN, Roggia C, Namba N, Novack D, Pacifici R. Estrogen deficiency induces bone loss by enhancing T cell production of TNFα. J Clin Invest. 2000. 106(10):1229-37

Cenci S, Weitzmann MN, Gentile MA, Aisa MC, Pacifici R. M-CSF neutralization and Egr-1 deficiency prevent ovariectomy-induced bone loss. J Clin Invest. 2000. 105(9):1279-1287

Total citations: 1,762; H Index: 17 (Scopus, April 2014)

 

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