Cenci profilo

Age related diseases

Simone Cenci, Head of Unit


Our lab studies the biology of normal plasma cells (PC), terminally differentiated effectors of antibody responses, and their malignant counterpart, multiple myeloma (2% of all cancer deaths). We are interested in the role of autophagy in PC ontogenesis and myeloma, in search for new molecular targets and markers of clinical use against PC cancers. Synergic studies on the skeletal microenvironment and bone cells explore the vicious relationship of myeloma with the bone marrow.

Curriculum vitae


2000 Specialization in Gerontology and Geriatrics, University of Perugia, Italy
1995 MD Degree, University of Perugia, Italy

Professional experiences

2015-today Head of Unit, San Raffaele Scientific Institute, Milan, Italy
2006-2015 Staff Scientist and Group leader, San Raffaele Scientific Institute, Milan, Italy
2003-2006 Junior Researcher, Molecular immunology, San Raffaele Scientific Institute, Milan, Italy
1998-2003 Research Associate, Division of Bone and Mineral Diseases, Internal Medicine, Washington University, St. Louis, MO, USA

Research grants (as Principal Investigator)

2017-2019 Italian Association for Cancer Research (AIRC) Investigator Grant
2016-2017 AIRC 5×1000 Molecular Clinical Oncology Extension Program
2014-2016 AIRC Investigator Grant
2011-2013 Multiple Myeloma Research Foundation (MMRF)
2010-2015 Italian Association for Cancer Research (Special Program 5×1000)
2010-2013 Italian Ministry of Health (Giovani Ricercatori)
2009-2011 European Calcified Tissue Society (Career Establishment Award)

Honors and awards

2014 Abilitazione Scientifica Nazionale (Italian Ministry of University and Research) as Professor of Internal Medicine, Pathology and Molecular and Applied Biology
2011 Multiple Myeloma Research Foundation (MMRF) Senior Research Award
2009 European Calcified Tissue Society (ECTS) Career Establishment Award, Wien, Austria
2009 Premio Giovane Ricercatore, Società Italiana Osteoporosi, Metabolismo Minerale e Malattie dello Scheletro (SIOMMMS), Turin, Italy
2000 Società Italiana Osteoporosi (SIOP) Young Investigator Award, Padova, Italy
2000 Young Investigator Award, American Society for Bone and Mineral Research, Toronto, Canada
1998 American Society for Bone and Mineral Research (ASBMR) Young Investigator Award, San Francisco, USA

Selected invited seminars

2017 EMBO Workshop, “B-cells in health and disease”, Girona, Spain
2016 Keystone Symposia, “B Cells at the Intersection of Innate and Adaptive Immunity”, Stockholm, Sweden
2015 International Forum on Immunology Research (IFIR), Berlin, Germany
2015 Institute of Ageing and Chronic Disease, University of Liverpool, UK
2014 Centrum für Chronische Immundefizienz, University of Freiburg, Germany
2014, 2013 Campus IFOM-IEO, Milan, Italy
2014, 2012 Annual Congress, European Calcified Tissue Society (ECTS)
2013, 2007 Imperial College, Clinical Sciences Centre, London, UK
2013 Center for Regenerative Therapies, University of Dresden, Germany
2012, 2010, 2005 Washington University School of Medicine, St. Louis, MO, USA
2011 University of Adelaide, Australia

International patents

WO2014068144A1: “Biomarkers of multiple myeloma development and progression”
PCT/EP2014/051518: “Method for antibody production”


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