sitia_perscopia

Protein transport and secretion

Roberto Sitia, Head of Unit

sitia.roberto@hsr.it


Over the last decade, the lab focused on two tightly related problems, the pathophysiology of B to plasma cell development and redox regulation/signaling in the early secretory pathway. Important traits d’union between the two are ERp44, a multifunctional chaperone we discovered a dozen years ago (Anelli et al., 2002, 2003 EMBO J), the assembly and quality control of polymeric IgM and the biogenesis and homeostatic control of the endoplasmic reticulum and secretory organelles.

Suggested links

Protein transportand secretion
International PhD program in Cellular and Molecular Biology

International PhD Course in Molecular Medicine

Journals
Antioxidant and Redox Signaling
Blood
EMBO J
EMBO Rep
Journal of Biological Chemistry
Nature
Science

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