sitia_perscopia

Protein transport and secretion

Roberto Sitia, Head of Unit

sitia.roberto@hsr.it


Over the last decade, the lab focused on two tightly related problems, the pathophysiology of B to plasma cell development and redox regulation/signaling in the early secretory pathway. Important traits d’union between the two are ERp44, a multifunctional chaperone we discovered a dozen years ago (Anelli et al., 2002, 2003 EMBO J), the assembly and quality control of polymeric IgM and the biogenesis and homeostatic control of the endoplasmic reticulum and secretory organelles.

Curriculum vitae

Education

1980 Specialization in Haematology (Magna cum laude) Medical School, University of Genoa, Italy
1977 MD Degree (Magna cum laude) Medical School, University of Genoa, Italy

Professional experiences

2000-today Professor of Molecular Biology, Università Vita-Salute San Raffaele, Milan, Italy
1990-today Group leader, San Raffaele Scientific Institute, Milan, Italy
2008-2014 Director, Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy
2005-2007 Dean of the School of Medicine, Università Vita-Salute San Raffaele, Milan, Italy
1998-2007 Deputy Director, Department of Functional Genomics and Molecular Biology,
San Raffaele Scientific Institute, Milan, Italy
1987-1990 Associate Professor, Immunogenetics, National Cancer Center, Genoa Italy
1986-1987 Visiting Investigator, Laboratory of Molecular Biology, Cambridge, UK
1982-1986 Assistant Professor, Molecular Biology, National Cancer Center, Genoa, Italy
1980-1982 Assistant Professor, Immunology and Transplantation, University of Genoa, Italy
1978-1979 Post Doctorate Fellow, Memorial Sloan Kettering Cancer Center, New York, USA

Fellowships and awards

2008 Feb-Dec Visiting professor, Institut Curie, Paris (France)
2006 Oct-Nov Visiting professor, Tokyo University (Japan)
1999 Jan-Feb Visiting professor, New South Wales University (Australia)
1986-1987 EMBO long-term fellow
1982-1984 Recipient of a NATO cooperation grant

Teaching activities and supervision of graduate students and post-doctoral fellows
Coordinator of the Course of Molecular Cell Biology (UniSR, Medical School) since 1998
14 graduate students trained over the last 10 years
12 postdoctoral fellows trained over the last 10 years

Honors and Professional societies
Elected Member of the European Molecular Biology Organisation (EMBO), 1992
Italian Associations of Cell Biology and Development (ABCD, twice in the steering committee)
Italian Society of Biochemistry and Molecular Biology (SIBMB)
American Society of Cell Biology (ASCB)
American Society of Biochemistry and Molecular Biology (ASBMB)

Organisation of meetings

2011 Co-Chair, “Reticulum”, Ascona (Switzerland)
2011 ETH Conference Quality Control, “Folding and Degradation of Proteins in the Endoplasmic”
2010 Chair, III Gordon Conference, “Thiol-based Redox Regulation and Signalling”, Il Ciocco (Italy)
2008 Vice-Chair, II Gordon Conference, “Thiol-based Redox Regulation and Signalling”, 2008, Il Ciocco (Italy)
2007 Chair of the ELSO Meeting, Dresden (Germany)

Institutional responsibilities

2001-today Faculty member, UniSR Medical School
2004-today Faculty member, PostGraduate course in Cell and Molecular Biology, UniSR, Milan, Italy
1994-2004 Faculty member, PostGraduate course in Cell and Molecular Biology, Open University, UK
2004-2007 Chair, EMBO Science and Society Committee
2002-2004 Member, EMBO Science and Society Committee
1998-2006 Co-Founder and member of the Steering Committee of ELSO
1993-1996 Member of the EMBO Course and Workshop Committee
1992 Founder and member of the Steering committee of the European Network of Immunology Institutes

Commissions of trust

  • Editor, The EMBO Journal (1998-present); EMBO Reports (1998-2010); The Journal of Biological Chemistry (2001-2006); PathoGenetics (2008-2011); Antioxidant Redox Signaling (2010-present); Nature Scientific Reports (2013-present)
  • Referee for most Molecular Cell Biology and Immunology journals, including: Nature, Science, Cell, Mol Cell, Immunity, Curr. Biol, PNAS, EMBO J. etc
  • Member of many evaluation committees, including: Academy of Finland; Medical Research Council, UK (International scientific committee 2001-2005); Austrian Research Minister, FWF; Israeli Science Foundation: Spanish Minister of Science and Education; National Institutes for Health; Swiss Science Foundation; Agencie Nationale de la Recherche (FR); Telethon; Wellcome Trust; Italian Ministries of Health and of University and Research; Consiglio Nazionale Ricerche
  • Consultant for small, medium and big enterprises, including Alchera Group, Italfarmaco, Roche, Shell
  • Co-founder of a small biotech company, Xeptagen
  • Scientific Advisory Board, Enciclopedia Italiana Treccani (1994-1998) and Editor of KOS a magazine merging science, medicine and culture (1998-2008)
  • Founder (2004) and member ever since of the Steering Committee of Bergamo Scienza (a popular science festival that in 2013 totalled over 100,000 visitors)

Major collaborations

2014-today J. Buchner, Munchen GE. Molecular mechanisms of IgM polymerization
2013-today A. Luini, Naples, I. Redox control of KDEL receptor signaling
2011-today R. Rizzuto & P. Pinton (Padua-Ferrara, IT). Control of Ca2+ and redox signaling by Ero1
2010-today K. Nagata, Kyoto Univ. JP. Intracellular transport of peroxiredoxin 4
2009-today K. Inaba, Tohoku Univ. JP. Structure of Ero1 and regulation of ERp44
2009-2010 D. Ron, Cambridge Univ. UK Context specific role of CHOP in B cells
2007-2008 P. Cosma, Naples-Barcelona. Control of SUMF1 secretion by ERp44
2007-today C.C. Wang, Chinese Academy of Science. Structure of ERp44, H2O2 scavenging by Gpx7
1999-2003 I. Braakman (Utrecht Univ. NL). Biogenesis and redox control of/in the ER

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