Protein transport and secretion

Roberto Sitia, Head of Unit

Over the last decade, the lab focused on two tightly related problems, the pathophysiology of B to plasma cell development and redox regulation/signaling in the early secretory pathway. Important traits d’union between the two are ERp44, a multifunctional chaperone we discovered a dozen years ago (Anelli et al., 2002, 2003 EMBO J), the assembly and quality control of polymeric IgM and the biogenesis and homeostatic control of the endoplasmic reticulum and secretory organelles.